WebJul 11, 2007 · In a recent study, patients with breast cancer having higher KLF5 expression had both shorter disease-free survival and overall survival and the result of the study showed that KLF5 expression is a prognostic factor for breast cancer (Tong et al. 2006). However, it plays an inhibitory role in cell growth in cancer cells as well. ... WebFigure 8.1. Relationships between steroid hormones and KLF5 in breast cells. ① Estrogen and ERα induce the expression of the EFP E3 ubiquitin ligase, which targets KLF5 for degradation in ERα-positive breast cancer cells. ② KLF5 interacts with ERα to suppress ERα-mediated transcription of c-Myc and CSTD in ERα-positive breast cancer cells. ③ …
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WebSep 3, 2024 · We previously reported that KLF5 forms a complex with TEAD4 and promotes breast cancer progression , and GCs also induces KLF5 through GR, and KLF5 partially mediated the GC-induced docetaxel and cisplatin resistance in TNBC . In this study, we demonstrated that GR binds to TEAD4 to promote TEAD4 transcription and is involved in … WebThe long noncoding RNA (lncRNA) LINC00152, also known as CYTOR, displays aberrant expression in various cancers. However, its clinical value and functional mechanisms in breast cancer remain insufficiently understood. Our study found that LINC00152 is significantly upregulated in breast cancer, and that it acts as an indicator of poor …
WebMay 16, 2009 · KLF5 has potential as a biomarker for diagnosis and prognosis in cancers and cardiovascular diseases. The expression of KLF5 mRNA associates with reduced survival in patients with breast cancer . … WebJan 1, 2013 · Most recently, KLF5 was shown to promote the self-renewal of ESC and to maintain ESC in an undifferentiated state (Jiang et al., 2008, Parisi et al., 2008). …
WebDec 10, 2013 · KLF5 function is aberrantly affected at the protein level in breast cancer, through excessive protein degradation or enhanced cytoplasmic localization 58, 63. Loss of the 13q21-q22 genomic region, … WebMar 19, 2024 · Breast cancer, cervical cancer, hepatocellular carcinoma, and bladder cancer are all aided by KLF5 [29–31]. Furthermore, KLF5 expression has been linked to a poor prognosis in lung cancer, and in vitro tests have shown that a decrease of KLF5 may overcome cisplatin resistance in lung cancer [ 32 ].
WebJun 19, 2009 · Krüpple-like transcription factor 5 (KLF5) is a zinc-finger transcription factor promoting cell survival and tumorigenesis in multiple cancers. A high expression level of …
WebHere, based on clinical database, we demonstrate a positive correlation between Kruppel-like factor 5 (KLF5) and YB-1 expression in breast cancer patients, but a negative correlation with that of Dachshund homolog 1 (DACH1). Mechanistically, YB-1 enhances KLF5 expression not only through transcriptional activation that can be inhibited by … flint mi to wixom miWebExpression of KLF5 (BTEB2, CKLF, IKLF) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. greater orlando aviation authority goaaWebAug 30, 2024 · In addition to KLF5, AXL is an EMT-induced regulator of cancer metastasis, controlled by Slug and Vimentin in breast cancer [17, 39–41]. Thus, the total AXL protein levels might also be lowered by EMT transcription factors, such as Slug or other transcription factors that have been changed by DCC-2036, which should be further … greater or greatestWebApr 24, 2024 · KLF5 depletion leads to breast cancer cell apoptosis and suppresses xenograft tumor growth in vivo [13, 14]. Importantly, pharmacological inhibition of KLF5 by mifepristone leads to suppression of TNBC stem cells . In conclusion, KLF5 is a potential therapeutic target for TNBC. greater orlando baseball associationAccording to our previous study, the expression of TNFAIP2 mRNA is induced by KLF5 in TSU-Pr1 cells.20 To further test whether TNFAIP2 is a KLF5 target gene, we first examined KLF5 and TNFAIP2 protein levels in three immortalized breast epithelial cell lines (MCF10A, 184A1 and 184B5), six TNBC cell lines … See more To test whether KLF5 positively regulates TNFAIP2 mRNA expression in breast epithelial cell lines, we first knocked down KLF5 in MCF10A (Figure 2a) and BT20 (Supplementary … See more It has been well established that KLF5 promotes cell proliferation in part through FGF-BP and mPGES1.17, 18, 29 Because the function of TNFAIP2 has never been studied in breast … See more Filopodia and lamellipodia regulate cell morphology, adhesion, migration and invasion.30 It has been reported that TNFAIP2 is associated with actin cytoskeleton and the … See more KLF5 has been shown to promote keratinocyte cell migration.19 To determine whether KLF5 promotes TNBC cell adhesion, … See more flint mi ward mapWebThe National Library of Medicine (NLM), on the NIH campus in Bethesda, Maryland, is the world's largest biomedical library and the developer of electronic information services that delivers data to millions of scientists, health professionals and members of the public around the globe, every day. greater orlando aviation authority parkingWebNov 11, 2024 · We conclude that USP3 confers drug resistance in breast cancer cells independently of KLF5. Discussion. KLF5 has been implicated as an oncogene and therapeutic target in a number of cancers including breast, colon, bladder, lung, stomach, and ovarian cancer . Therefore, it is important to thoroughly understand the upstream … flint mi to wisconsin dells