Carboxymethyl-9-acridanone
WebMouse, but not human STING, can also bind vascular disrupting agents 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and the antiviral small molecule 10-carboxymethyl-9-acridanone (CMA) to induce type I IFN production, suggesting a species-specific drug effect on the STING-mediated host response (Conlon J et al. 2013; Cavlar … WebIn recent years, both interferons and inductors of endogenous interferon production find increasing use in clinical practice. The latter agents are characterized by high antiviral and immunomodulatory activity in the absence of serious side effects, which makes it possible to prescribe long courses …
Carboxymethyl-9-acridanone
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Web10-carboxymethyl-9-acridanone (CMA, 43) (Fig. 11 a) is a potent type I IFN inducer for antiviral therapy [177]. In previous study, 43 with appreciable antiviral activity was … WebDMXAA [18,19,28], and the anti-viral CMA (10-carboxymethyl-9-acridanone) [20]. On the basis of binding studies, crystal structures and pathway analysis, these compounds are thought to activate mouse STING in the same way as the natural cyclic dinucleotide ligands [18,21]. In addition, CDNs themselves
WebMay 15, 2013 · Abstract Extensive research on antiviral small molecules starting in the early 1970s has led to the identification of 10-carboxymethyl-9-acridanone (CMA) as a … WebGiven as a pretreatment, H-151 was shown to attenuate pathological features of autoinflammatory disease in mouse models, reducing systemic cytokine responses in mice treated with the STING agonist 10-carboxymethyl-9-acridanone (CMA)
WebApr 14, 2016 · CMA (10-carboxymethyl-9-acridanone) is an antiviral compound that can induce type I IFNs . Both DMXAA and CMA were recently cocrystallized with STING ( 9, … WebNew choline and halogen derivatives of CMA (9-oxo-10-acridine acetic acid) were investigated as interferon (IFN) inducers in mice and in the mouse bone marrow-derived macrophage cultures. Two of the choline derivatives, DMCMA and CSCMA, were active IFN inducers presumably because they were hydrolyze …
Web9-Aminoacridine. 9-Aminoacridine for synthesis. CAS 90-45-9, molar mass 194.23 g/mol. 9-Aminoacridine MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, …
WebBesides the established T-cell property of producing gamma interferon (IFN-gamma), murine T cells additionally possess the ability to produce IFN-alpha and IFN-beta when appropriate inducers such as 10-carboxymethyl-9-acridanone (CMA) or Newcastle disease virus (NDV) are used. Interleukin 2 (IL-2)-d … howl with black hairWeb1-(Carbomethoxymethyl)aziridine C5H9NO2 CID 26865 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological ... howl wallpaper 4kWebGet latest price of Crystal Acm-9 Herbicide, 240 g,Packaging Size - 240 g, Packaging Type - Pack, Brand - Acm-9, Technical Name - Clodinafop Propargyl 9% + Metribuzin 20% WP, … howl windWebBiological Activity. 9-Aminoacridine is a highly fluorescent dye used clinically as a topical antiseptic and experimentally as a mutagen, an intracellular pH indicator and a negative … high waisted panel jeansWebCytokine mRNA expression was studied in human long-term cell cultures of different origin: J-96 and J-41 (monocytic leukemia), SW-13 (paradrenal adenocarcinoma), and MT-4 (T-cell leukemia), in response to IFN-alpha and IFN inducers (kagocel and cycloferon). Cytokine mRNA level in the cell cultures w … howl wisconsinWebThe 10-carboxymethyl-9-acridanone (CMA) anion and the N-methylglucamine cation are shown. The MA absorption spectrum is presented at the bottom. Source publication +3 Meglumine acridone … howl with orange hairWebApr 19, 2013 · Extensive research on antiviral small molecules starting in the early 1970s has led to the identification of 10-carboxymethyl-9-acridanone (CMA) as a potent type I interferon (IFN) inducer. Up to date, the mode of action of this antiviral molecule has remained elusive. Here we demonstrate that CMA mediates a cell-intrinsic type I IFN … high waisted palm bikini