Cytoplasmic retention
Webdegradation [14, 17]. In contrast, the MAPK triggered linker phosphorylation of Smads in cytoplasm diminishes the receptor type I responsible Smad phosphorylation and favours the cytoplasmic retention and degradation of Smad. More information is provided in the main text.Note: Numbers in square brackets indicate relevant references included WebOct 17, 2024 · Cytoplasmic fusion is not followed by karyogamy, resulting in a dikaryotic cell. After cell fusion on the plant surface, the G2 cell cycle arrest is sustained, and the single dikaryotic cell grows in a polar …
Cytoplasmic retention
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WebOct 17, 2024 · This new understanding of the determinants of nuclear retention and cytoplasmic export provides a deeper understanding of how information flow is regulated in eukaryotic cells. Ultimately these processes promote the evolution of complexity in eukaryotes by shaping the genomic content through constructive neutral evolution. WebJul 14, 1998 · The temperature-sensitive mutant tsp53 val135 accumulates in the cytoplasm of cells kept at the non-permissive temperature (39°C), but is rapidly transported into the cell nucleus at the...
WebJan 21, 1997 · M-phase promoting factor or maturation promoting factor, a key regulator of the G 2 → M transition of the cell cycle, is a complex of cdc2 and a B-type cyclin. We have previously shown that Xenopus cyclin B1 has five sites of Ser phosphorylation, four of which map to a recently identified cytoplasmic retention signal (CRS). The CRS appears to … WebJun 6, 2014 · The results introduce a new paradigm where cytokine treatment prolongs nuclear retention simultaneous with decreasing rather than increasing the rate of nuclear import. ... It would thus appear that the C-terminal tail of STAT3α contributes to cytoplasmic retention of STAT3 in the cytoplasm under basal conditions, with S727 within it helping ...
WebMar 1, 2013 · A cytoplasm retention signal would, in theory, not be affected by these interventions, whereas we observed nuclear accumulation of Htt in the setting of inhibition of nuclear export. Given its high degree of evolutionary conservation, beyond the four amino acid NES motif, it is highly plausible that N17 contains overlapping, but distinct ... WebNov 6, 2024 · AE1 coexpression could reduce the ER/Golgi retention of GPB, but not of GPBtail or GPBhead. ... Most C-terminal, cytoplasmic residues of GPA (25 amino acids) were omitted. The cytoplasmic region of GPA has been reported to support AE1 forward trafficking . The pre-TMD of GPA (residues 61–70) supports the anion transport activity …
WebJun 1, 2024 · Here, we report that Mastermind-like 1 and 2 (MAML1/2) are indispensable for YAP/TAZ nuclear localization and transcriptional activities. Ectopic expression or depletion of MAML1/2 induces nuclear translocation or cytoplasmic retention of YAP/TAZ, respectively. Additionally, mutation of the MAML nuclear localization signal, as well as its …
WebThe cytoplasmic retention of TFE3 by mTOR in preadipocytes is sensitive to amino acids but not to the presence of growth factor-rich FBS dialyzed to remove amino acids (dFBS) (Fig. 4A). In the absence of FLCN, TFE3 is nuclear even in the presence of amino acids ( Fig. 4 A), consistent with the reported role of FLCN as a transducer of amino acid ... fluid filled rash bumpsWebDec 7, 2024 · Due to its potent cytoplasmic retention activity, we named this region (352–357 aa) Cytoplasmic Anchoring Signal, CAS. T o further elucidate the working … fluid filled sac in mouthWebFeb 1, 2003 · The interphase cytoplasmic location of cyclin B1/Cdc2 reflects continuous, albeit slow, nuclear import and much more rapid nuclear export. In contrast, the sudden nuclear accumulation of the complex before entry into mitosis reflects a marked increase in the import rate, with a concomitant inhibition of cyclin B1 nuclear export. fluid filled sac in the scrotumWebApr 7, 2015 · First, cytoplasmic retention of YAP/TAZ, which was promoted either by high cell density or CytoD treatment, correlated with the induction of ciliogenesis. Second, depletion of YAP/TAZ caused a ... fluid filled sac around the testiclesgreenethorpe post officeWebApr 1, 2006 · Nucleo-cytoplasmic distribution of β-catenin is regulated by retention. J Cell Sci (2006) 119 (7): 1453–1463. β-catenin is the central signalling molecule of the … greenethorpe real estateWebJun 20, 2000 · Retention by STAT2 may serve to regulate the activity of free p48 and/or guarantee that cytoplasmic pools of preassociated STAT2:p48 are available for rapid … fluid filled small bowel loops causes