WebThis proton gradient is then used by the ATP synthase complex to produce ATP from ADP and inorganic phosphate. CoQ6 is an integral component of the ETC, as it is involved in the biosynthesis of ubiquinone, a key electron carrier in the chain. The ETC comprises four protein complexes (I-IV) that are arranged in the mitochondrial inner membrane. Phosphate carrier protein, mitochondrial is a protein that in humans is encoded by the SLC25A3 gene. The encoded protein is a transmembrane protein located in the mitochondrial inner membrane and catalyzes the transport of phosphate ions across it for the purpose of oxidative phosphorylation. There are two … See more The SLC25A3 gene is located on the q arm of chromosome 12 in position 23.1 and spans 8,376 base pairs. The gene has 9 exons and produces a 40.1 kDa protein composed of 362 amino acids. The encoded protein … See more The encoded protein (PHC) catalyzes the transport of phosphate from the cytosol into the mitochondrial matrix, either by proton See more The encoded protein interacts with PPIF; this interaction is impaired by CsA. See more • Dolce V, Fiermonte G, Messina A, Palmieri F (1992). "Nucleotide sequence of a human heart cDNA encoding the mitochondrial phosphate carrier". DNA Sequence. 2 (2): … See more Mutations in this gene can cause mitochondrial phosphate carrier deficiency (MPCD), a fatal disorder of oxidative phosphorylation. Symptoms include lactic acidosis, … See more • Solute carrier family See more
Loss of the mitochondrial phosphate carrier SLC25A3 induces …
WebMar 21, 2014 · The mitochondrial phosphate carrier (PiC) is a member of the solute carrier 25A family that has a critical role in OXPHOS, serving as the primary route for inorganic phosphate (Pi) import... WebLOC127002728 phosphate carrier protein, mitochondrial-like [ (Chinese mitten crab)] Gene ID: 127002728, updated on 4-Oct-2024. Summary Other designations. phosphate carrier … income tax laws 2021
The mammalian phosphate carrier SLC25A3 is a …
WebAug 13, 2024 · In 2 sibs with mitochondrial phosphate carrier deficiency, Mayr et al. (2007) identified homozygosity for a missense mutation in the alternatively spliced exon 3A of the SLC25A3 gene (G72E; 600370.0001), which produces the heart/muscle-specific isoform of mitochondrial phosphate carrier protein.In both patients, functional investigation of intact … WebSep 1, 2024 · Here, we investigated cardiac pathways activated in response to mitochondrial energy dysfunction by studying mice with cardiomyocyte-specific loss of the mitochondrial phosphate carrier (SLC25A3), an established model that develops cardiomyopathy as a result of defective mitochondrial ATP synthesis. WebTwo novel thiazolidine compounds, GW604714X and GW450863X, were found to be potent inhibitors of mitochondrial respiration supported by pyruvate but not other substrates. Direct measurement of pyruvate transport into rat liver and yeast mitochondria confirmed that these agents inhibited the mitochondrial pyruvate carrier (MPC) with K(i) values <0.1 … income tax laws for senior citizens